Eligibility information

Who Can Take Part?

The following information provides a general guide to eligibility criteria. The research team will confirm eligibility individually. Please read carefully before registering interest.

Please note: The eligibility criteria below are provided as a general guide only. The research team will review all registrations of interest and confirm eligibility on an individual basis. Meeting the criteria below does not guarantee enrolment. Participation is entirely voluntary.

Inclusion criteria

You may be eligible if…

The following criteria are indicative only. All eligibility is confirmed by the research team.

  • You are a postmenopausal female, confirmed by at least 12 consecutive months since your last menstrual cycle
  • You are aged between 45 and 65 years at the time of enrolment
  • You have one or more recognised risk factors for dementia (e.g., family history of dementia, cardiovascular risk factors, subjective cognitive concerns) — the research team will assess this as part of the eligibility process
  • You are able to provide written informed consent
  • You are able to read and understand English sufficiently to complete the study assessments
  • You are able to complete the required study components (in person or remotely, as applicable)
  • You have access to a device (e.g., computer, tablet, smartphone) and internet connection if remote assessments are required
Exclusion criteria

This study may not be suitable if…

The following are general exclusion indicators. The research team will assess each registration individually.

  • You have a current diagnosis of dementia, mild cognitive impairment (MCI), or a neurodegenerative condition
  • You currently use creatine monohydrate or creatine-containing supplements, or have used them within the past 2 months
  • You have a known kidney or liver condition that may be affected by creatine supplementation (as assessed by the research team)
  • You are currently taking menopausal hormone therapy (MHT) — please discuss with the research team if you have questions about this criterion
  • You have a current or recent major psychiatric condition that would affect your ability to participate in assessments
  • You are currently enrolled in another clinical trial or research study involving a dietary supplement or pharmaceutical intervention
  • You have a known allergy or intolerance to creatine monohydrate or any components of the study supplement

Not sure if you are eligible?

If you are unsure about any criterion, please register your interest anyway. The research team is happy to discuss your individual circumstances and will not exclude you without review.

After you register

What happens next?

Registering interest is the first step only. It does not commit you to participating in the study.

1

Register your interest

Complete the online expression of interest form via REDCap. This takes approximately 5–10 minutes and collects basic eligibility information. Completion of this form is not enrolment in the study.

~5–10 minutes
2

Research team review

The research team will review your responses and contact you within 2 business days to discuss your eligibility and the study in more detail.

Team reviews responses
3

Screening assessment

If initial eligibility criteria are met, you will be invited to a formal telephone screening assessment. This may include health questions, a brief cognitive screen, and review of your medical history with the research team. You will be provided with the Participant Information Sheet and given adequate time to consider your participation before providing written informed consent. You may ask questions at any point.

Conducted by research team
4

Informed consent

If you are eligible and wish to proceed with participation, you will be provided with a referral for your local pathology centre and you will complete your baseline assessments. You may ask questions or withdraw at any point.

Your decision — no pressure
5

Enrolment & baseline

Following this, you will be enrolled into the study and randomised into either the creatine monohydrate or placebo group. The 12-week intervention then begins.

Study begins
For clinicians & GPs

Healthcare provider referrals

Healthcare providers may refer patients who may be eligible. Referral is informal and does not constitute enrolment. The research team will confirm all eligibility.

A clinician information summary is available on request. Please contact the research team via the details below.

Contact the research team

Referral enquiries

Refer a patient

If you are a GP, specialist, or allied health professional and believe a patient may meet the eligibility criteria, please contact the study team:

📧 menocog@westernsydney.edu.au
📞 +61 422 774 769

Ready to register interest?

Registering is not a commitment. The research team will contact you about next steps if appropriate.

Register Interest